Background: Leptin is potentially involved in the correction of early postnatal growth of infants having deviated from their genetic trajectory in utero.Aim: To analyse the potential mediating role of cord blood leptin level in the association between neonatal anthropometry and early postnatal growth in the mother-child EDEN cohort.Subjects and methods: We included term newborns with information on leptin, birth weight and length, and weight and length SD-score changes over the first 2 months. The Baron and Kenny method was used to quantify the mediation contribution of leptin in the association between neonatal anthropometry and postnatal growth, considering several confounders. Analyses were stratified to consider sexual dimorphism.Results: A 1 SD higher birth weight was associated with a lower 2-months weight variation of 0.27 (0.18; 0.36) SD and a 0.16 (0.06; 0.26) SD, in boys and girls, respectively. Leptin explained 20% and 25% of these associations, respectively. Leptin did not mediate the association between birth length and birth-to-2 months length variation.Conclusion: Our results suggest that cord blood leptin may not be involved in the negative association between birth length and postnatal length growth but may play a modest mediating role in early postnatal catch-up or catch-down in weight.

中文翻译：

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脐血瘦素水平是否介导新生儿体重与产后生长之间的联系？EDEN母婴队列研究的结果。

背景：瘦素可能在纠正子宫内遗传轨迹偏离的婴儿的出生后早期生长中起作用。目的：分析脐带血瘦素水平在新生儿人体测量学与母亲出生后早期生长之间的关联中的潜在中介作用。 EDEN队列儿童。对象和方法：我们纳入足月新生儿，其中包括瘦素，出生体重和身长以及体重和身长SD得分在前两个月的变化等信息。考虑到一些混杂因素，使用Baron和Kenny方法来量化瘦素在新生儿人体测量学与出生后生长之间的关联中的介导作用。结果：出生体重增加1 SD与2个月体重降低0.27（0.18; 0。36）男孩和女孩的SD和0.16（0.06; 0.26）SD。瘦素分别解释了这些关联的20％和25％。瘦素未介导出生时长与出生至2个月时长变化之间的关联。结论：我们的结果表明，脐血瘦素可能不参与出生时长与产后时长增长之间的负相关关系，但可能起适度的中介作用在产后早期追赶或追赶体重。