The proper organization of the physical genome is essential to facilitate DNA-templated processes from transcription to replication to DNA repair. Genome-wide studies over the past two decades have provided us with a detailed understanding of the positions and modification states of nucleosomes across the genomes of many organisms, as well as an increasingly mature understanding of chromosome organization at the kilobase to megabase scale. Here, we explore chromatin organization at intermediate scales of ∼2-10 nucleosomes, from early views supporting a secondary structural element known as the 30nm fiber to more recent 'sea of nucleosomes' models.

中文翻译：

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染色质纤维的中尺度组织。

物理基因组的正确组织对于促进从转录到复制再到DNA修复的DNA模板化过程至关重要。在过去的二十年中，对全基因组的研究为我们提供了对许多生物体基因组中核小体的位置和修饰状态的详细了解，以及对从千碱基到兆碱基规模的染色体组织的日益成熟的了解。在这里，我们从约2-10个核小体的中等规模探索染色质组织，从早期观点出发，即支持被称为30nm纤维的二级结构元素，到最近的“核小体海洋”模型。