Here we propose that the upper bound marginal stability of proteins is a universal property that includes macro-molecular complexes and is not affected by molecular changes such as mutations and post-translational modifications. We theorize that its existence is a consequence of Afinsen's thermodynamic hypothesis rather than a result of an evolutionary process. This result enables us to conjecture that neutral evolution should also be, with respect to protein stability, a universal phenomenon.

中文翻译：

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蛋白质的边际稳定性：原子的抖动和摆动如何与中性进化相关联。

在这里，我们提出蛋白质的上限边际稳定性是一种普遍属性，包括大分子复合物，不受分子变化（如突变和翻译后修饰）的影响。我们的理论是它的存在是阿芬森热力学假设的结果，而不是进化过程的结果。这一结果使我们能够推测，就蛋白质稳定性而言，中性进化也应该是一种普遍现象。