Calstabin2, also named FK506 binding protein 12.6 (FKBP12.6), is a subunit of ryanodine receptor subtype 2 (RyR2) macromolecular complex, an intracellular calcium channel. Studies from our and other's lab have shown that hippocampal calstabin2 regulates spatial memory. Calstabin2 and RyR2 are widely distributed in the brain, including the amygdala, a key brain area involved in the regulation of emotion including fear. Little is known about the role of calstabin2 in fear memory. Here, we found that genetic deletion of calstabin2 impaired long-term memory in cued fear conditioning test. Knockdown calstabin2 in the lateral amygdala (LA) by viral vector also impaired long-term cued fear memory expression. Furthermore, calstabin2 knockout reduced long-term potentiation (LTP) at both cortical and thalamic inputs to the LA. In conclusion, our present data indicate that calstabin2 in the LA plays a crucial role in the regulating of emotional memory.

中文翻译：

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杏仁核外侧钙稳定蛋白2在恐惧记忆调节中的作用。

Calstabin2，也称为FK506结合蛋白12.6（FKBP12.6），是ryanodine受体亚型2（RyR2）大分子复合物（细胞内钙通道）的亚基。我们和其他实验室的研究表明，海马calstabin2调节空间记忆。Calstabin2和RyR2广泛分布在大脑中，包括杏仁核，杏仁核是参与调节情绪（包括恐惧）的关键大脑区域。关于calstabin2在恐惧记忆中的作用知之甚少。在这里，我们发现，在暗示恐惧条件测试中，calstabin2的基因缺失损害了长期记忆。病毒载体击倒外侧杏仁核（LA）中的calstabin2也损害了长期提示的恐惧记忆表达。此外，钙稳定蛋白2敲除降低了LA的皮质和丘脑输入处的长期增强（LTP）。结论，