Multiple reports for brain functional and structural alterations in patients with Crohn's disease (CD) were published. The current study aimed to meta-analyze the existing neuroimaging data and hence produce a brain map revealing areas with functional and structural differences between patients with CD and healthy controls. Original studies published until 2019 were identified from Scopus, Web of Science and PubMed databases, and included into the analysis if they reported relevant results from task-related or resting state functional magnetic resonance imaging (fMRI or rsfMRI) or voxel-based morphometry (VBM), in the form of standardized brain coordinates based on whole-brain analysis. The brain coordinates and sample size of significant results were extracted from eligible studies to be meta-analyzed with the activation likelihood estimation method using the GingerALE software. Sixteen original studies comprised of a total of 865 participants fulfilled the inclusion criteria. Compared to healthy controls, patients with CD had reduced resting state brain connectivity in the paracentral lobule and cingulate gyrus as well as reduced grey matter volume in the medial frontal gyrus. No significant results were found vice versa. These neural correlates allow a better understanding on the effects of CD on the pain expectation, emotion, and quality of life of patients and potentially serve as useful biomarkers for evaluating treatment efficacy.

中文翻译：

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克罗恩病患者大脑的结构和功能变化：激活可能性估计的荟萃分析。

发表了有关克罗恩病（CD）患者脑功能和结构改变的多份报告。当前的研究旨在对现有的神经影像数据进行荟萃分析，从而制作出一张脑图，揭示出CD患者与健康对照者在功能和结构上存在差异的区域。从Scopus，Web of Science和PubMed数据库中识别出直到2019年为止发表的原始研究，如果它们报告了任务相关或静止状态功能磁共振成像（fMRI或rsfMRI）或基于体素的形态计量学（VBM）的相关结果，则将其纳入分析），以基于全脑分析的标准化脑坐标形式呈现。从符合条件的研究中提取大脑坐标和重要结果的样本大小，然后使用GingerALE软件通过激活可能性估计方法进行荟萃分析。总共865名参与者组成的16项原始研究符合纳入标准。与健康对照相比，CD患者的中央下小叶和扣带回的静息状态大脑连通性降低，内侧额中回的灰质体积降低。反之亦然，未发现明显的结果。这些神经相关性可以更好地了解CD对患者的疼痛预期，情绪和生活质量的影响，并有可能作为评估治疗效果的有用生物标记。总共865名参与者组成的16项原始研究符合纳入标准。与健康对照相比，CD患者的中央下小叶和扣带回的静息状态大脑连通性降低，内侧额中回的灰质体积降低。反之亦然，未发现明显的结果。这些神经相关性可以更好地了解CD对患者的疼痛预期，情绪和生活质量的影响，并有可能作为评估治疗效果的有用生物标记。总共865名参与者组成的16项原始研究符合纳入标准。与健康对照相比，CD患者的中央下小叶和扣带回的静息状态大脑连通性降低，内侧额中回的灰质体积降低。反之亦然，未发现明显的结果。这些神经相关性可以更好地了解CD对患者的疼痛预期，情绪和生活质量的影响，并有可能作为评估治疗效果的有用生物标记。反之亦然，未发现明显的结果。这些神经相关性可以更好地了解CD对患者的疼痛预期，情绪和生活质量的影响，并有可能作为评估治疗效果的有用生物标记。反之亦然，未发现明显的结果。这些神经相关性可以更好地了解CD对患者的疼痛预期，情绪和生活质量的影响，并有可能作为评估治疗效果的有用生物标记。