We studied the possibility of developing an autism model based on chronic prenatal psychological stress caused by variable frequency ultrasound 20-45 kHz. The offspring of female rats stressed during pregnancy demonstrated reduced time of social contacts in the social interaction test, increased anxiety in the open-field test, and memory impairment in the Morris water maze test in comparison with the control (intact) rat offspring. We also found a reducing trend in the BDNF gene expression in the amygdala in males of the experimental group. The results showed the possibility of developing the animal autism model based on prenatal stress.

中文翻译：

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超声诱导产前应激后大鼠后代的社会和认知障碍

我们研究了基于由 20-45 kHz 变频超声引起的慢性产前心理压力开发自闭症模型的可能性。与对照（完整）大鼠后代相比，在怀孕期间受到压力的雌性大鼠的后代在社交互动测试中表现出减少社交接触的时间，在开放场测试中增加了焦虑，在莫里斯水迷宫测试中出现了记忆障碍。我们还发现实验组男性杏仁核中 BDNF 基因表达的下降趋势。结果显示了基于产前压力开发动物自闭症模型的可能性。