Background

The first documented outbreak of dengue which included cases with haemorrhage occurred in Papua New Guinea in 2016.

Aim

To document the presentation and outcome of children with dengue in Port Moresby.

Methods

This prospective cross-sectional descriptive study was conducted in Port Moresby General Hospital during a 6-month period from 6 January to 6 July 2016. Altogether, 165 children aged 1–14 years who met the WHO criteria for probable dengue were assessed and treated. Clinical features, presence of warning signs and signs of severe dengue, date of onset, management and outcome were recorded. Blood specimens were collected for serological testing and full blood count.

Results

The median age was 6 years (interquartile range 3–8). Eighty-eight (53%) children had no warning signs and were managed as outpatients. Of the 165 patients, 42 (25%) had abdominal pain, 28 (17%) had bleeding and 3 (2%) had clinical evidence of fluid accumulation. The median (IQR) lowest platelet count in those tested was 34 × 10⁹/L (22–54). Two children were transfused with packed red blood cells and one received a platelet transfusion. No child developed dengue shock and none died. Non-structural protein 1 (NS1) and dengue IgM were positive in 122/144 (85%) and 36/111 (32%) of blood samples, respectively. 150/151 blood samples tested for dengue were positive on one or more tests.

Conclusion

There is the potential for future outbreaks of increased severity in Papua New Guinea. Surveillance, mosquito reduction initiatives and health education programmes are needed to reduce the impact of future outbreaks.

中文翻译：

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2016年巴布亚新几内亚首都区爆发儿童登革热。

背景

2016 年，巴布亚新几内亚首次出现登革热爆发，其中包括出血病例。

目的

记录莫尔兹比港登革热儿童的表现和结果。

方法

这项前瞻性横断面描述性研究于 2016 年 1 月 6 日至 7 月 6 日在莫尔兹比港综合医院进行，为期 6 个月。总共有 165 名 1-14 岁符合 WHO 可能登革热标准的儿童接受了评估和治疗。记录临床特征、严重登革热的警告信号和体征、发病日期、管理和结果。收集血液标本进行血清学检测和全血细胞计数。

结果

中位年龄为 6 岁（四分位距为 3-8）。八十八名 (53%) 儿童没有任何警告迹象，并作为门诊病人接受治疗。在 165 名患者中，42 名 (25%) 有腹痛，28 名 (17%) 有出血，3 名 (2%) 有积液的临床证据。测试者的中位 (IQR) 最低血小板计数为 34 × 10 ⁹ /L (22–54)。两名儿童输注了浓缩红细胞，一名儿童接受了血小板输注。没有孩子出现登革热休克，也没有人死亡。非结构蛋白 1 (NS1) 和登革热 IgM 分别在 122/144 (85%) 和 36/111 (32%) 的血液样本中呈阳性。150/151 份登革热血液样本在一项或多项测试中呈阳性。

结论

巴布亚新几内亚未来可能爆发更严重的疫情。需要进行监测、减少蚊子的举措和健康教育计划，以减少未来爆发的影响。