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Function and mechanisms of memory destabilization and reconsolidation after retrieval.
Proceedings of the Japan Academy, Series B ( IF 3.1 ) Pub Date : 2020-01-01 , DOI: 10.2183/pjab.96.008
Satoshi Kida 1
Affiliation  

Memory retrieval is not a passive process. When a memory is retrieved, the retrieved memory is destabilized, similar to short-term memory just after learning, and requires memory reconsolidation to re-stabilize the memory. Recent studies characterizing destabilization and reconsolidation showed that a retrieved memory is not always destabilized and that there are boundary conditions that determine the induction of destabilization and reconsolidation according to certain parameters, such as the duration of retrieval and the memory strength and age. Moreover, the reconsolidation of contextual fear memory is not independent of memory extinction; rather, these memory processes interact with each other. There is an increasing number of findings suggesting that destabilization following retrieval facilitates the modification, weakening, or strengthening of the original memory, and the resultant updated memory is stabilized through reconsolidation. Reconsolidation could be targeted therapeutically to improve emotional disorders such as post-traumatic stress disorder and phobia. Thus, this review summarizes recent findings to understand the mechanisms and function of reconsolidation.

中文翻译:

检索后记忆不稳定和重新巩固的功能和机制。

记忆检索不是一个被动的过程。当记忆被检索时,检索到的记忆是不稳定的,类似于刚刚学习后的短期记忆,需要记忆重新巩固来重新稳定记忆。最近对不稳定和再巩固特征的研究表明,检索到的记忆并不总是不稳定的,并且存在根据某些参数(例如检索持续时间、记忆强度和年龄)确定不稳定和再巩固诱导的边界条件。此外,情境恐惧记忆的重新巩固并不独立于记忆消退。相反,这些记忆过程是相互作用的。越来越多的研究结果表明,检索后的不稳定会促进原始记忆的修改、削弱或加强,并且由此产生的更新记忆通过重新巩固而稳定。重新巩固可以作为治疗的目标,以改善情绪障碍,如创伤后应激障碍和恐惧症。因此,本综述总结了最近的发现,以了解再巩固的机制和功能。
更新日期:2020-01-01
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