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Novel strategies for rapid identification and susceptibility testing of MRSA.
Expert Review of Anti-infective Therapy ( IF 5.7 ) Pub Date : 2020-05-13 , DOI: 10.1080/14787210.2020.1760842
Masako Mizusawa 1 , Karen C Carroll 2
Affiliation  

Introduction

Methicillin-resistant Staphylococcus aureus (MRSA) is associated with adverse clinical outcomes and increased morbidity, mortality, length of hospital stay, and health-care costs. Rapid diagnosis of MRSA infections has been associated with positive impact on clinical outcomes.

Areas covered

We searched relevant papers in PubMed for the last 10 years. In major papers, we scanned the bibliographies to ensure that important articles were included. This review describes screening and diagnostic test methods for MRSA and their analytical performances with a focus on rapid molecular-based assays including those that are on the horizon. Future novel technologies will allow more rapid detection of phenotypic resistance. In the case of whole-genome sequencing, detection of mutations may predict resistance, transmission, and virulence.

Expert opinion

Currently there are many diagnostic options for the detection of MRSA in surveillance and clinical samples. In general, these are highly accurate and have resulted in improvements in targeted management and reduction in hospital or intensive care unit length of stay for both MSSA and MRSA. Impact on mortality has been variable. Promising novel technologies will not only accurately identify pathogens and detect their resistance markers but will allow discovery of virulence determinants that might further affect patient management.



中文翻译:

快速鉴定和药敏试验的新策略。

介绍

耐甲氧西林的金黄色葡萄球菌(MRSA)与不良的临床结果,发病率,死亡率,住院时间和医疗保健费用增加相关。快速诊断MRSA感染已对临床结果产生积极影响。

覆盖区域

我们搜索了过去十年中PubMed中的相关论文。在主要论文中,我们扫描了参考书目,以确保包括重要文章。这篇综述描述了MRSA的筛选和诊断测试方法及其分析性能,重点是基于分子的快速测定,包括即将出现的测定。未来的新技术将允许更快速地检测表型耐药性。在全基因组测序的情况下,检测突变可以预测耐药性,传播和毒力。

专家意见

当前,在监视和临床样本中有许多诊断选项可用于检测MRSA。通常,这些都是高度准确的,并且可以针对MSSA和MRSA改善目标管理并减少住院或重症监护病房的住院时间。对死亡率的影响是可变的。有希望的新技术不仅可以准确地识别病原体并检测其抗药性标记,还可以发现可能进一步影响患者管理的毒力决定因素。

更新日期:2020-05-13
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