Postmortem changes occurring in human carotid body were simulated on the Wistar rat model. It was shown that light, dark, and pyknotic (progenitor) subtypes of human carotid body cells are an artifact and cannot be used in clinical practice to study the characteristics of various human diseases. The differences between the control group of healthy individuals and individuals with the various pathologies are most likely due to the different levels of premortal hypoxia that the tissue had been exposed to. Moreover, widespread antigens used in practice were divided into 2 groups by their tolerance to autolysis: stable and unstable ones. This can be useful for the development of immunohistochemical test algorithms for the diagnostics on autopsy material.

中文翻译：

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黑暗和祖颈动脉体细胞的免疫组织化学研究：人工制品还是真正的亚型？

在 Wistar 大鼠模型上模拟了人颈动脉体中发生的死后变化。研究表明，人类颈动脉体细胞的亮、暗和固缩（祖）亚型是人造的，不能在临床实践中用于研究各种人类疾病的特征。健康个体的对照组与具有各种病理的个体之间的差异很可能是由于组织暴露于不同水平的生前缺氧所致。此外，实践中广泛使用的抗原根据它们对自溶的耐受性分为两组：稳定的和不稳定的。这对于开发用于尸检材料诊断的免疫组织化学测试算法非常有用。