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Distribution of Ferrihydrite Nanoparticles in the Body and Possibility of Controlling Them in an Isolated Organ by a Permanent Magnetic Field
Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2020-04-01 , DOI: 10.1007/s10517-020-04803-y
E V Inzhevatkin 1 , E D Osipova 1 , K V Shadrin 1 , V G Pakhomova 1 , A P Rupenko 1 , N G Maksimov 1 , V P Ladygina 1 , R N Yaroslavtsev 1, 2 , S V Stolyar 1, 2
Affiliation  

We studied the distribution of ferrihydrite nanoparticles isolated from bacteria Klebsiella oxytoca in the whole body in vivo and in a cultured isolated organ (liver). The possibility of controlling these nanoparticles in the body using a magnetic field was assessed. One hour after intravenous injection of ferrihydrite nanoparticles to mice, their accumulation was observed in the liver, lungs, and kidneys. Experiment with cultured isolated rat liver showed that these nanoparticles can be controlled by a magnetic field and the influence of magnetic nanoparticles on the liver over 1 h does not lead to destruction of liver cells associated with the release of the marker enzyme AST. These results show the possibility of using magnetic nanoparticles as a system for controlled drug delivery in the body.

中文翻译:

水铁矿纳米粒子在体内的分布以及通过永久磁场在离体器官中控制它们的可能性

我们研究了从催产克雷伯菌中分离出的水铁矿纳米颗粒在体内和培养的离体器官(肝脏)中的分布。评估了使用磁场控制体内这些纳米粒子的可能性。在向小鼠静脉注射水铁矿纳米颗粒一小时后,观察到它们在肝脏、肺和肾脏中积聚。对培养的离体大鼠肝脏进行的实验表明,这些纳米颗粒可以通过磁场进行控制,并且磁性纳米颗粒对肝脏的影响超过 1 小时不会导致与标记酶 AST 释放相关的肝细胞破坏。这些结果显示了使用磁性纳米颗粒作为体内受控药物递送系统的可能性。
更新日期:2020-04-01
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