We studied the effect of acute vital stress on the parameters of the hemostasis system in young and old Wistar rats. The psychotraumatic effect was simulated as a situation of emotional stress at the sight of a predator (Indian python) catching and eating a conspecific. In young rats, acute vital stress was followed by inhibition of platelet aggregation, hypercoagulation by the external pathway and final stages of plasma hemostasis, and a decrease in fibrinogen and antithrombin III levels against the background of fibrinolysis activation. In old animals, increased platelet count with reduced aggregation capacity, hypocoagulation by the internal pathway of the plasma hemostasis activation, signs of thrombinemia (a 2-fold increase in soluble fibrin-monomer complexes), an increase in antithrombin III, and inhibition of the fibrinolytic system were observed. Age-related changes in the hemostasis parameters in rats were determined before and after stress exposure.

中文翻译：

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止血系统对大鼠急性生命应激的反应

我们研究了急性生命应激对年轻和年老 Wistar 大鼠止血系统参数的影响。心理创伤效应被模拟为在看到捕食者（印度蟒蛇）捕捉和吃掉同种动物时的情绪压力情况。在年轻大鼠中，急性生命应激之后是血小板聚集的抑制、外部途径的高凝状态和血浆止血的最后阶段，以及在纤维蛋白溶解激活的背景下纤维蛋白原和抗凝血酶 III 水平的降低。在老年动物中，血小板计数增加，聚集能力降低，血浆止血激活的内部途径引起的低凝状态，凝血酶血症的迹象（可溶性纤维蛋白-单体复合物增加 2 倍），抗凝血酶 III 增加，并观察到纤维蛋白溶解系统的抑制。在压力暴露之前和之后确定大鼠止血参数的年龄相关变化。