Pharmacokinetics of suppository forms of bacteriophages was studied on male Chinchilla rabbits. Suppositories with various composition of bacteriophages were administered once per rectum to rabbits, and the presence of phage particles was estimated in the blood, urine, and feces over 24 h. Pharmacokinetic study showed that the phages were detected in the blood, urine, and feces at various terms of the experiment irrespective of the size of viral particles, which confirmed the possibility of their systemic effects after rectal administration. Thus, the use of suppository form of bacteriophages can ensure the presence of phage particles even in infection foci that cannot directly contact with the preparation.

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噬菌体栓剂的药代动力学分析

在雄性龙猫兔上研究了栓剂形式的噬菌体的药代动力学。将含有各种噬菌体成分的栓剂按直肠给药一次给兔子，并在 24 小时内估计血液、尿液和粪便中存在噬菌体颗粒。药代动力学研究表明，无论病毒颗粒的大小如何，在实验的各个时期，在血液、尿液和粪便中均检测到噬菌体，这证实了它们在直肠给药后可能产生全身效应。因此，使用栓剂形式的噬菌体可以确保即使在不能直接接触制剂的感染灶中也存在噬菌体颗粒。