Recently we evaluated by actigraphy the rest-activity circadian rhythm (RAR) in breast cancer (BC) survivors at 5 years from primary diagnosis, as well as in a control group with similar age and body mass index (BMI). RAR, analyzed by Cosinor method, resulted significantly different in BC survivors compared to healthy subjects: BC survivors showed lower values of MESOR and Amplitude (A), while acrophase (φ) was similar in the two groups.

Now, using non-parametric methods we have detected Interdaily Stability (IS), Intradaily Variability (IV), nocturnal activity (L5), and daily activity (M10) on the same sample of previous study: 15 BC survivors at 5 years from the primary diagnosis (mean age = 56.7 ± 6.6 yrs; mean BMI = 24.5 ± 3.8 Kg/m²) and 13 healthy controls (mean age = 54.4 ± 7.2 yrs; mean BMI = 25.2 ± 2.8 Kg/m²).

The non-parametric indices showed that in BC-group IV was significantly higher than in Ctrl-group (0.86 vs. 0.65 a.u. in BC and Ctrl, respectively; p <.01), while L5 (11.27 vs. 34.41 a.c. in BC and Ctrl, respectively; p <.0001) and M10 (326.82 vs. 428.07 a.c. in BC and Ctrl, respectively; p <.01) were significantly lower compared to Ctrl-group.

The data suggest that BC patients need constant clinical assessment of RAR characteristics along the years following the primary diagnosis. The analysis of RAR in all its components, parametric and non-parametric, is important to detect alterations in the sleep-wake cycle and can be useful for developing new strategies for health protection, such as structured and tailored physical activity programs, to improve circadian activity level in order to raise the quality of life in BC survivors.

最近，我们通过触觉描记法评估了从初次诊断起5年的乳腺癌（BC）幸存者以及年龄和体重指数（BMI）相似的对照组的静息活动性昼夜节律（RAR）。通过Cosinor方法分析的RAR与健康受试者相比，BC幸存者的结果显着不同：BC幸存者的MESOR和振幅（A）值较低，而两组的顶相（φ）相似。

现在，使用非参数方法，我们在先前研究的同一样本中检测到了日间稳定性（IS），日内变异性（IV），夜间活动（L5）和每日活动（M10）：距样本5年的15个BC幸存者初步诊断（平均年龄= 56.7±6.6岁；平均BMI = 24.5±3.8 Kg / m ²）和13位健康对照（平均年龄= 54.4±7.2岁；平均BMI = 25.2±2.8 Kg / m ²）。

非参数指标显示，BC组IV显着高于Ctrl组（BC和Ctrl分别为0.86和0.65 au；p <.01），而L5组（BC和Ctrl中分别为11.27和34.41 ac）。与Ctrl-group相比，分别为Ctrl；p <.0001）和M10（在BC和Ctrl中分别为326.82与428.07 ac；p <.01）要低得多。

数据表明，在初次诊断后的几年中，BC患者需要对RAR特征进行持续的临床评估。对RAR的所有组成部分（参数性和非参数性）进行分析对于检测睡眠-唤醒周期的变化非常重要，对于开发新的健康保护策略（例如结构化和量身定制的体育锻炼计划）以改善昼夜节律很有帮助活动水平，以提高卑诗省幸存者的生活质量。