Coagulase-negative staphylococci (CoNS) are part of the microbiota of human skin and rarely linked with soft tissue infections. In recent years, CoNS species considered as one of the major nosocomial pathogens and can cause several infections such as catheter-acquired sepsis, skin infection, urinary tract infection, endophthalmitis, central nervous system shunt infection, surgical site infections, and foreign body infection. These microorganisms have a significant impact on human life and health and, as typical opportunists, cause peritonitis in individuals undergoing peritoneal dialysis. Moreover, it is revealed that these potential pathogens are mainly related to the use of indwelling or implanted in a foreign body and cause infective endocarditis (both native valve endocarditis and prosthetic valve endocarditis) in patients. In general, approximately eight percent of all cases of native valve endocarditis is associated with CoNS species, and these organisms cause death in 25% of all native valve endocarditis cases. Moreover, it is revealed that methicillin-resistant CoNS species cause 60 % of all prosthetic valve endocarditis cases. In this review, we describe the role of the CoNS species in infective endocarditis, and we explicated the reported cases of CoNS infective endocarditis in the literature from 2000 to 2020 to determine the role of CoNS in the process of infective endocarditis.

凝固酶阴性葡萄球菌（CoNS）是人类皮肤微生物群的一部分，很少与软组织感染相关。近年来，CoNS物种被认为是主要的医院病原体之一，可引起多种感染，例如导管获得性败血症，皮肤感染，尿路感染，眼内炎，中枢神经系统分流感染，手术部位感染和异物感染。这些微生物对人类的生命和健康具有重大影响，并且作为典型的机会主义者，在进行腹膜透析的个体中引起腹膜炎。此外，揭示了这些潜在病原体主要与留置或植入异物的使用有关，并且引起患者的感染性心内膜炎（天然瓣膜心内膜炎和人工瓣膜心内膜炎）。一般来说，在所有天然瓣膜心内膜炎病例中，约有8％与CoNS物种相关，这些微生物在所有天然瓣膜心内膜炎病例中造成25％的死亡。此外，还发现耐甲氧西林的CoNS物种占所有人工瓣膜心内膜炎病例的60％。在这篇综述中，我们描述了CoNS种类在感染性心内膜炎中的作用，并且我们从2000年到2020年对文献报道的CoNS感染性心内膜炎病例进行了阐述，以确定CoNS在感染性心内膜炎过程中的作用。