Liver cancer is thought as the most common human malignancy worldwide, and hepatocellular carcinoma (HCC) accounts for nearly 90% liver cancer. Due to its poor early diagnosis and limited treatment, HCC has therefore become the most lethal malignant cancers in the world. Recently, molecular targeted therapies showed great promise in the treatment of HCC, and novel molecular therapeutic targets is urgently needed. KIF15 is a microtubule-dependent motor protein involved in multiple cell processes, such as cell division. Additionally, KIF15 has been reported to participate in the growth of various types of tumors; however, the relation between KIF15 and HCC is unclear. Herein, our study investigated the possible role of KIF15 on the progression of HCC and found that KIF15 has high expression in tumor samples from HCC patients. KIF15 could play a critical role in the regulation of cell proliferation of HCC, which was proved by in vitro and in vivo assays. In conclusion, this study confirmed that KIF15 could be a novel therapeutic target for the treatment of HCC.

中文翻译：

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KIF15促进肝细胞癌的增殖和生长。

肝癌被认为是全球最常见的人类恶性肿瘤，肝细胞癌（HCC）占近90％的肝癌。由于早期诊断的差和治疗的限制，HCC已成为世界上最致命的恶性肿瘤。近来，分子靶向疗法在肝癌的治疗中显示出巨大的希望，并且迫切需要新的分子治疗靶标。KIF15是一种微管依赖的运动蛋白，涉及多种细胞过程，例如细胞分裂。另外，据报道，KIF15参与了各种类型肿瘤的生长。但是，KIF15和HCC之间的关系尚不清楚。在本文中，我们的研究调查了KIF15在HCC进程中的可能作用，并发现KIF15在HCC患者的肿瘤样本中具有高表达。KIF15可能在肝癌细胞增殖的调控中起关键作用，这已在体外和体内实验中得到证实。总之，这项研究证实，KIF15可能是治疗HCC的新靶点。