Shewanella algae is an emerging marine zoonotic pathogen and accounts for considerable mortality and morbidity in compromised hosts. However, there is scarce literature related to the understanding of the genetic background of virulence determinants in S. algae. In this study, we aim to determine the occurrence of common virulence genes in S. algae using whole-genome sequence and comparative genomic analysis. Comparative genomics reveals putative-virulence genes related to bile resistance, chemotaxis, hemolysis, and motility. We detected the existence of hlyA, hlyD, and hlyIII involved in hemolysis. We also found chemotaxis gene cluster cheYZA operon and cheW gene. The results provide insights into the genetic basis underlying pathogenicity in S. algae.

中文翻译：

---

比较基因组学揭示了希瓦氏菌藻中的致病性相关基因座。

希瓦氏菌藻是一种新兴的海洋人畜共患病原体，在受损宿主中造成相当大的死亡率和发病率。然而，很少有文献与对藻类中毒力决定簇的遗传背景的了解有关。在这项研究中，我们旨在使用全基因组序列和比较基因组分析来确定海藻中常见毒力基因的发生。比较基因组学揭示了与胆汁抵抗，趋化性，溶血性和运动性有关的推定毒性基因。我们发现存在靶向hlyA，hlyD和溶血素III参与溶血。我们还发现趋化性基因簇cheYZA操纵子和咀嚼基因。结果提供了洞悉藻致病性的遗传基础的见解。