Journal of Drug Targeting ( IF 4.5 ) Pub Date : 2020-04-24 , DOI: 10.1080/1061186x.2020.1757102 Mingliang Fan 1 , Minxing Jiang 2
Abstract
Core-shell nanoparticles have grown in popularity in the past few years due to their versatile features and multiple biomedical applications as drug delivery systems. In order to improve bioavailability and reduce adverse effects, the biomimetic concept has been integrated into core-shell architectural designs. In this regard, the ‘camouflage’ shell comprised of various cellular membranes renders these nanoparticles a multifunctional platform that combines the merits of native cellular membranes with the advantages of biomaterials. Since leukocytes have a specific tropism for inflammatory or tumour sites and can infiltrate into these lesions, the marriage of leukocyte cell membrane shell with functional nanoparticle core is expected to achieve long time circulation, targeted delivery and improved ability of overcoming certain physiological barriers. In this review, we focus mainly on the recent development of nanoparticles cloaked with the leukocyte membrane and their applications in different biomedical fields of interest, including cancer therapy, inflammatory regulation and immune modulation. Additionally, current challenges and future prospects of leukocyte membrane coated core-shell nanoparticles are also briefly discussed.
中文翻译:
用于生物医学应用的具有白细胞膜伪装的核壳纳米疗法。
摘要
核壳纳米粒子由于其多功能特性和作为药物递送系统的多种生物医学应用,在过去几年中越来越受欢迎。为了提高生物利用度并减少不利影响,仿生概念已被整合到核壳建筑设计中。在这方面,由各种细胞膜组成的“伪装”外壳使这些纳米粒子成为一个多功能平台,将天然细胞膜的优点与生物材料的优点相结合。由于白细胞对炎症或肿瘤部位具有特定的趋向性,可以渗透到这些病变中,白细胞细胞膜壳与功能性纳米颗粒核的结合有望实现长时间循环,靶向递送和提高克服某些生理障碍的能力。在这篇综述中,我们主要关注用白细胞膜包裹的纳米粒子的最新发展及其在不同生物医学领域的应用,包括癌症治疗、炎症调节和免疫调节。此外,还简要讨论了白细胞膜包被的核壳纳米粒子的当前挑战和未来前景。