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Cancer risk in patients with psoriasis: should we be paying more attention?
Expert Review of Clinical Immunology ( IF 4.4 ) Pub Date : 2020-04-24 , DOI: 10.1080/1744666x.2020.1754194
Nikolai Dyrberg Loft 1, 2 , Sofie Vaengebjerg 1, 2 , Lone Skov 1, 2
Affiliation  

Introduction

Psoriasis is a chronic-immune-mediated disease affecting 2–4% of the western population. The disease is associated with several co-morbidities including an increased risk of cancer. Concerns have been raised whether psoriasis itself, the psoriasis-associated risk factors, or the treatment of psoriasis might lead to an increased risk of cancer.

Areas covered

We reviewed the literature on cancers associated with psoriasis and discuss some of the potential mechanisms behind the observed associations.

Expert opinion

Patients with psoriasis have an increased risk of cancers overall and some site-specific cancers especially non-melanoma skin cancer, lymphoma, and lung cancer. The increased risk is most likely due to a combination of the chronic low-grade inflammation in psoriasis, risk factors for cancer associated with psoriasis, and the treatment of psoriasis. Future research should investigate the contribution of the individual mechanisms. Additionally, multiple new specific immunomodulatory treatments for psoriasis have been introduced during recent years and it is important to monitor and investigate whether these treatments confer an increased risk of cancers. Lastly, as patients with psoriasis have an increased alcohol use, smoke more than the general population and as psoriasis has been linked to obesity, promotion of a healthy lifestyle is key in the prevention of certain cancer types.



中文翻译:

银屑病患者的癌症风险:我们应该更加关注吗?

简介

银屑病是一种慢性免疫介导的疾病,影响了 2-4% 的西方人口。该疾病与多种合并症有关,包括患癌症的风险增加。人们担心银屑病本身、银屑病相关风险因素或银屑病治疗是否会导致癌症风险增加。

覆盖区域

我们回顾了有关银屑病相关癌症的文献,并讨论了所观察到的关联背后的一些潜在机制。

专家意见

银屑病患者的整体癌症风险和某些特定部位癌症的风险增加,尤其是非黑色素瘤皮肤癌、淋巴瘤和肺癌。风险增加很可能是由于银屑病的慢性低度炎症、银屑病相关癌症的危险因素以及银屑病治疗的综合作用。未来的研究应该调查个体机制的贡献。此外,近年来引入了多种针对银屑病的新型特异性免疫调节疗法,重要的是监测和调查这些疗法是否会增加患癌症的风险。最后,由于银屑病患者的酒精使用量增加,吸烟量超过一般人群,并且银屑病与肥胖有关,

更新日期:2020-04-24
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