Objective

An investigation of the prevalence of medication persistence and associated factors in order to inform effective strategies for improving medication persistence.

Methods

A systematic review of the literature from 2010 to the present was performed, using the PRISMA protocol. Primary and empirical observational studies of adult ischemic stroke or transient ischemic attack patients were included. PubMed, CINAHL, Web of Science, Cochrane Library, and PsycInfo databases were searched using the key terms stroke, ischemic stroke, medication persistence, medication adherence, and patient compliance.

Results

Of four hundred twenty-eight journal articles retrieved, a final 18 articles were included. Short-term medication persistence was 46.2–96.7%, and long-term medication persistence was 41.7–93.0%. Identified hospital-related factors for medication persistence were stroke unit care, in-hospital medical complications, and early follow-up visit. Demographic factors for medication persistence were older age, and high/adequate financial status; disease-related factors were disease history, stroke subtype, and symptom severity. Age less than 75, female sex, comorbidity, antiplatelet medication switch, and polypharmacy were identified as factors of medication nonpersistence.

Conclusions

Stroke patients’ medication persistence decreases over time, and persistence on antiplatelets, anticoagulants, and statin was poor. Several factors were associated with medication persistence, and these factors should be considered in future secondary preventative strategies.

中文翻译：

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与缺血性脑卒中患者药物持续性相关的因素：系统评价。

目的

调查药物持续性的患病率和相关因素，以便为改善药物持续性提供有效策略。

方法

使用PRISMA协议对2010年至今的文献进行了系统的综述。包括成人缺血性卒中或短暂性脑缺血发作患者的主要和经验观察性研究。使用以下关键词搜索中风，缺血性中风，药物持久性，药物依从性和患者依从性，搜索PubMed，CINAHL，Web of Science，Cochrane Library和PsycInfo数据库。

结果

在检索到的248条期刊文章中，最后18篇文章被收录。短期用药持续率为46.2–96.7％，长期用药持续率为41.7–93.0％。已确定的与药物持久性相关的医院相关因素是中风病房护理，院内医疗并发症和早期随访。药物持续性的人口统计学因素是年龄大，财务状况高/适当；与疾病相关的因素包括疾病史，中风亚型和症状严重程度。年龄小于75岁，女性，合并症，抗血小板药物转换和多药房被确定为药物持久性的因素。

结论

中风患者的药物持久性随时间而降低，抗血小板，抗凝剂和他汀类药物的持久性较差。药物持久性与多种因素有关，在以后的二级预防策略中应考虑这些因素。