In order to maintain functional robustness and species integrity, organisms must ensure high fidelity of the genome duplication process. This is particularly true during early development, where cell division is often occurring both rapidly and coherently. By studying the extreme limits of suppressing DNA replication failure due to double fork stall errors, we uncover a fundamental constant that describes a trade-off between genome size and architectural complexity of the developing organism. This constant has the approximate value N U ≈ 3 × 10 12 basepairs, and depends only on two highly conserved molecular properties of DNA biology. We show that our theory is successful in interpreting a diverse range of data across the Eukaryota.

中文翻译：

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3 tera-basepairs作为健壮的DNA复制的基本限制。

为了维持功能的鲁棒性和物种完整性，生物必须确保基因组复制过程的高保真度。在早期发育中尤其如此，在早期发育中，细胞分裂经常快速且连贯地发生。通过研究抑制双叉失速错误导致的DNA复制失败的极限，我们发现了一个基本常数，该常数描述了基因组大小与发育中生物体的结构复杂性之间的折衷。该常数的近似值为NU≈3×10 12个碱基对，并且仅取决于DNA生物学的两个高度保守的分子特性。我们证明了我们的理论成功地解释了整个真核生物的各种数据。