Bisphenol A (BPA) is suspected to be associated with several chronic metabolic diseases. The aim of the present study was to review previous epidemiological studies that examined the relationship between BPA exposure and the risk of obesity. PubMed, Web of Science, and Embase databases were systematically searched by 2 independent investigators for articles published from the start of database coverage until January 1, 2020. Subsequently, the reference list of each relevant article was scanned for any other potentially eligible publications. We included observational studies published in English that measured urinary BPA. Odds ratios with corresponding 95% confidence intervals for the highest versus lowest level of BPA were calculated. Ten studies with a sample size from 888 to 4793 participants met our inclusion criteria. We found a positive correlation between the level of BPA and obesity risk. A dose-response analysis revealed that 1-ng/mL increase in BPA increased the risk of obesity by 11%. The similar results were for different type of obesity, gender, and age.

中文翻译：

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对双酚A和肥胖症的风险进行流行病学证据的荟萃分析的系统评价。

双酚A（BPA）被怀疑与几种慢性代谢性疾病有关。本研究的目的是回顾以前的流行病学研究，该研究检查了BPA暴露与肥胖风险之间的关系。由2名独立研究人员系统搜索了PubMed，Web of Science和Embase数据库，以查找从数据库覆盖范围开始到2020年1月1日为止发表的文章。随后，对每篇相关文章的参考列表进行了扫描，以寻找其他可能合格的出版物。我们纳入了以英语发表的测量尿液双酚A的观察性研究。计算了最高和最低BPA水平下具有相应95％置信区间的赔率。十项研究的样本量为888至4793名参与者，符合我们的纳入标准。我们发现BPA水平与肥胖风险呈正相关。剂量反应分析表明，双酚A浓度每升高1 ng / mL，肥胖风险增加11％。类似的结果适用于不同类型的肥胖，性别和年龄。