Background Acute mountain sickness has become a heavily researched topic in recent years. However, the genetic mechanism and effects have not been elucidated. Our goal is to construct a gene co-expression network to identify the key modules and hub genes associated with high altitude hypoxia. Results The GSE46480 dataset of rapidly transported healthy adults with acute mountain sickness was selected and analyzed by weighted gene co-expression network analysis (WGCNA) to construct a co-expression network. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the data set were carried out using Database for Annotation Visualization and Integrated Discovery (DAVID), and the hub genes were selected. We found that the turquoise module was most significantly correlated with acute mountain sickness. The functional enrichment analysis showed that the turquoise module was related to the apoptotic process, protein transport , and translation processes. The metabolic pathway analysis identified hsa03010:ribosome and hsa04144:endocytosis as the most important pathways in the turquoise module. Ten top 10 hub genes (M RPL3, PSMC6, AIMP1, HAT1, DPY30, ATP5L, COX7B, UQCRB, DPM1, and COMMD6 ) for acute mountain sickness were identified. Conclusion One module and 10 hub genes were identified, which were related to acute mountain sickness. The reference provided by this module may help to elucidate the mechanism of acute mountain sickness. In addition, the hub genes may be used in the future as a biomarker and therapeutic target for accurate diagnosis and treatment.

中文翻译：

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急性高山病相关基因共表达网络和枢纽基因的研究

背景 急性高山病近年来已成为研究热点。然而，其遗传机制和作用尚未阐明。我们的目标是构建一个基因共表达网络来识别与高海拔缺氧相关的关键模块和枢纽基因。结果选取GSE46480快速转运健康成人急性高山病数据集，通过加权基因共表达网络分析（WGCNA）构建共表达网络。使用注释可视化和集成发现数据库（DAVID）对数据集进行基因本体论（GO）和京都基因和基因组百科全书（KEGG）富集分析，并选择枢纽基因。我们发现绿松石模块与急性高山病最显着相关。功能富集分析表明，绿松石模块与细胞凋亡过程、蛋白质转运和翻译过程有关。代谢途径分析确定 hsa03010:ribosome 和 hsa04144:endocytosis 是绿松石模块中最重要的途径。确定了急性高山病的 10 个前 10 位枢纽基因（M RPL3、PSMC6、AIMP1、HAT1、DPY30、ATP5L、COX7B、UQCRB、DPM1 和 COMMD6）。结论 鉴定出与急性高山病相关的1个模块和10个枢纽基因。本模块提供的参考资料可能有助于阐明急性高山病的机制。此外，hub基因未来可能会被用作生物标志物和治疗靶点，用于准确诊断和治疗。