Tumor metastasis is a major cause of cancer treatment failure and death, and chemotherapy efficiency for gastric cancer patients is usually unsatisfactory due to tumor cell metastasis, poor targeting and serious adverse reactions. In this study, a kind of R8GD modified epirubicin plus tetrandrine liposomes was prepared to enhance the antitumor efficiency via killing tumor cells, destroying tumor metastasis and inhibiting energy supply for tumor cells. In order to investigate the antitumor efficiency of the targeting liposomes, morphology observation, intracellular uptake, cytotoxic effects, and inhibition on tumor metastasis and energy supply were carried out in vitro, and tumor-bearing mice models were established to investigate the antitumor efficiency in vivo. In vitro results showed that R8GD modified epirubicin plus tetrandrine liposomes with ideal physicochemical properties could kill the most tumor cells, inhibit tumor metastasis and cut off energy supply for tumor cells. In vivo results exhibited that R8GD modified epirubicin plus tetrandrine liposomes could enhance the accumulation in tumor site and display an obvious antitumor efficiency. Therefore, R8GD modified epirubicin plus tetrandrine liposomes could be used as a potential therapy for treatment of gastric cancer.

中文翻译：

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R8GD修饰的表柔比星联合粉防己碱脂质体通过抑制肿瘤转移增强抗肿瘤疗效

肿瘤转移是癌症治疗失败和死亡的主要原因，而胃癌患者的化疗效果往往因肿瘤细胞转移、靶向性差、不良反应严重等原因而不尽如人意。本研究制备了一种R8GD修饰的表柔比星加粉防己碱脂质体，通过杀死肿瘤细胞、破坏肿瘤转移和抑制肿瘤细胞的能量供应来提高抗肿瘤效率。为了研究靶向脂质体的抗肿瘤效率，在体外进行形态观察、细胞内摄取、细胞毒作用、抑制肿瘤转移和能量供应，并建立荷瘤小鼠模型以研究体内抗肿瘤效率. 体外实验结果表明，具有理想理化性质的R8GD修饰的表柔比星加粉防己碱脂质体可以杀死大部分肿瘤细胞，抑制肿瘤转移，切断肿瘤细胞的能量供应。体内实验结果表明，R8GD 修饰的表柔比星加粉防己碱脂质体可以增强在肿瘤部位的积累并显示出明显的抗肿瘤效率。因此，R8GD 修饰的表柔比星加粉防己碱脂质体可作为治疗胃癌的潜在疗法。