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Management of Citrus sinensis peels for protection and treatment against gastric ulcer induced by ethanol in rats.
Biomarkers ( IF 2.6 ) Pub Date : 2020-05-07 , DOI: 10.1080/1354750x.2020.1759693
Asmaa Aboul Naser 1 , Eman Younis 1 , Amal El-Feky 2 , Marwa Elbatanony 2 , Manal Hamed 1
Affiliation  

Introduction: Stomach ulcer is one of the most prevalent disorders worldwide. The study was aimed to isolate and characterize the major polymethoxylated flavonoids in Citrus sinensis peels petroleum ether extract and investigate its protective and curative effect on gastric ulcer.Material and methods: Some spectral analyses were used for identification of the isolated compounds from the petroleum ether extract of Citrus sinensis peels. One oral dose (0.5 ml/100 g b.wt.) of absolute ethanol was orally given to rats after starvation for 24 h to induce gastric ulcer. To explore the protective and curative role of the plant extract, it was orally (250 mg/kg b.wt.) given for 1 week either before or post-ulcer induction. A reference drug, ranitidine (100 mg/kg b.wt.), was also evaluated. Stomach acidity, gastric volume, lesion counts, glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), succinate dehydrogenase (SDH), lactate dehydrogenase (LDH), acid phosphatase (AP), interlukin-10 (IL-10) and prostaglandin E2 (PGE2) were estimated. Stomach histopathological features were monitored.Results: Nine polymethoxy flavonoids were identified from the extract. Treatment with C. sinensis peels extract recorded amelioration in all parameters.Conclusion: Citrus sinensis petroleum ether peels extract had protective and curative effects against gastric ulcer. Therefore, the extract recorded anti-secretory, anti-ulcerative, anti-inflammatory, and antioxidant effects. Its healing action exceeded its protective role due to its richness in polymethoxylated flavonoids.

中文翻译:

柑橘皮的管理对大鼠乙醇引起的胃溃疡的保护和治疗。

简介:胃溃疡是全球最普遍的疾病之一。本研究旨在分离和表征柑桔皮石油醚提取物中的主要聚甲氧基黄酮类化合物,并研究其对胃溃疡的保护和治疗作用。材料与方法:进行了一些光谱分析,以鉴定从石油醚提取物中分离出的化合物。柑桔皮。饥饿24小时后,给大鼠口服一次口服剂量(0.5 ml / 100 g b.wt.)的无水乙醇以诱发胃溃疡。为了探索植物提取物的保护和治疗作用,在溃疡诱导之前或之后口服给予(250 mg / kg b.wt.)1周。还评估了参考药物雷尼替丁(100 mg / kg体重)。胃酸度,胃容量,病变计数,谷胱甘肽(GSH),估计了超氧化物歧化酶(SOD),丙二醛(MDA),琥珀酸脱氢酶(SDH),乳酸脱氢酶(LDH),酸性磷酸酶(AP),白细胞介素10(IL-10)和前列腺素E2(PGE2)。结果:从提取物中鉴定出九种聚甲氧基黄酮类化合物。结论:柑桔石油醚果皮提取物对胃溃疡具有保护和治疗作用。因此,该提取物具有抗分泌,抗溃疡,抗炎和抗氧化作用。由于其富含聚甲氧基黄酮,其愈合作用超出了其保护作用。评估了酸性磷酸酶(AP),白细胞介素10(IL-10)和前列腺素E2(PGE2)。结果:从提取物中鉴定出九种聚甲氧基黄酮类化合物。结论:柑桔石油醚果皮提取物对胃溃疡具有保护和治疗作用。因此,该提取物具有抗分泌,抗溃疡,抗炎和抗氧化作用。由于其富含聚甲氧基黄酮,其愈合作用超出了其保护作用。评估了酸性磷酸酶(AP),白细胞介素10(IL-10)和前列腺素E2(PGE2)。结果:从提取物中鉴定出九种聚甲氧基黄酮类化合物。结论:柑桔石油醚果皮提取物对胃溃疡具有保护和治疗作用。因此,该提取物具有抗分泌,抗溃疡,抗炎和抗氧化作用。由于其富含聚甲氧基黄酮,其愈合作用超出了其保护作用。结论:柑桔石油醚果皮提取物对胃溃疡具有保护和治疗作用。因此,该提取物具有抗分泌,抗溃疡,抗炎和抗氧化作用。由于其富含聚甲氧基黄酮,其愈合作用超出了其保护作用。结论:柑桔石油醚果皮提取物对胃溃疡具有保护和治疗作用。因此,该提取物具有抗分泌,抗溃疡,抗炎和抗氧化作用。由于其富含聚甲氧基黄酮,其愈合作用超出了其保护作用。
更新日期:2020-05-07
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