Background: Systemic Sclerosis (SSc), also known as scleroderma, is an autoimmune rheumatic disease, which is clinically subdivided into two major subgroups; limited (lcSSc) and diffuse cutaneous scleroderma (dcSSc). Even though the SSc etiologies remains unclear, some HLA and non-HLA genetic variants have been associated with the disease.

中文翻译：

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希族塞人人口对系统性硬化症的遗传易感性：一项初步研究。

背景：系统性硬化症（SSc），也称为硬皮病，是一种自身免疫性风湿性疾病，临床上可分为两个主要亚组。受限（lcSSc）和弥漫性皮肤硬皮病（dcSSc）。尽管SSc的病因仍不清楚，但某些HLA和非HLA遗传变异与该疾病有关。