I want to enrich the debate about the ethics and governance of human germline editing (HGE) by emphasizing an underappreciated, yet important, set of concerns regarding exclusionary practices, norms, and efforts that impede a broader discussion about the subject. The possibility for establishing a binding, global, regulatory framework is influenced by economic and geopolitical factors as well as historical processes and sociopolitical problems, such as anti-scientific social movements and the politicization of science. Likewise, it is influenced by different understanding, epistemic resources, and goals between the CRISPR/genome editing community and the rest of society. In this Perspective, I explain the concept of “techno-scientific colonialist paternalism” and why it negatively affects our discussion around HGE. I also discuss the pitfalls of scientific self-regulation, and finally, I advocate that the implementation of HGE should cease to allow time and care for a thoughtful global discussion to emerge.

中文翻译：

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人类种系基因组编辑的伦理学和全球治理：技术科学的殖民主义家长制问题。

我想通过强调关于排他性实践，规范和努力的一整套未得到充分理解但很重要的担忧，从而阻碍有关该主题的广泛讨论，从而丰富有关人类种系编辑（HGE）的道德与治理的辩论。建立具有约束力的全球监管框架的可能性受到经济和地缘政治因素以及历史进程和社会政治问题（例如反科学社会运动和科学政治化）的影响。同样，它受到CRISPR /基因组编辑社区与社会其他成员之间不同理解，认知资源和目标的影响。在此观点中，我将解释“技术-科学的殖民主义家长式统治”的概念，以及它为什么会对围绕HGE的讨论产生负面影响。