Symptomatic stress urinary incontinence (SUI) and pelvic organ prolapse (POP) refractory to conservative management with pelvic floor muscle training or vaginal pessaries may warrant surgical intervention with different forms of biologic or synthetic material. However, in recent years, several global regulatory agencies have issued health warnings and recalled several mesh products due to an increase in complications such as mesh erosion, infection, chronic pain, and perioperative bleeding. At present, current surgical treatment strategies for SUI and POP are aimed at developing biological graft materials with similar mechanical properties to established synthetic meshes, but with improved tissue integration and minimal host response. This narrative review aims to highlight recent studies related to the development of biomimetic and biologic graft materials as alternatives to traditional synthetic materials for SUI/POP repair in female patients. We also investigate complications and technical limitations associated with synthetic mesh and biological biomaterials in conventional SUI and POP surgery. Our findings demonstrate that newly developed biologic grafts have a lower incidence of adverse events compared to synthetic biomaterials. However there remains a significant disparity between success in preclinical trials and long-term clinical translation. Further characterization on the optimal structural, integrative, and mechanical properties of biological grafts is required before they can be reliably introduced into clinical practice for SUI and POP surgery.

中文翻译：

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压力性尿失禁和盆腔器官脱垂：重新审视生物移植材料。

有症状的压力性尿失禁 (SUI) 和盆腔器官脱垂 (POP) 难以通过盆底肌肉训练或阴道子宫托进行保守治疗，可能需要使用不同形式的生物或合成材料进行手术干预。但近年来，由于网片侵蚀、感染、慢性疼痛、围手术期出血等并发症增多，全球多家监管机构发布健康警告并召回多款网片产品。目前，SUI 和 POP 的当前手术治疗策略旨在开发与已建立的合成网具有相似机械性能的生物移植材料，但具有改善的组织整合和最小的宿主反应。这篇叙述性评论旨在强调与开发仿生和生物移植材料作为女性患者 SUI/POP 修复的传统合成材料的替代品相关的最新研究。我们还调查了与传统 SUI 和 POP 手术中的合成网状物和生物生物材料相关的并发症和技术限制。我们的研究结果表明，与合成生物材料相比，新开发的生物移植物的不良事件发生率较低。然而，临床前试验的成功与长期临床转化之间仍然存在显着差异。在将生物移植物可靠地引入 SUI 和 POP 手术的临床实践之前，需要进一步表征生物移植物的最佳结构、综合和机械性能。