Purpose: To investigate the aqueous humor and serum levels of selected cytokines and vascular endothelial growth factor (VEGF) in diabetic patients, implicating their role in the pathogenesis of diabetic eye complications.Materials and methods: Atotal of 65 patients (27 males and 38 females) who underwent cataract surgery were recruited into the study. The study group consisted of 30 cataract patients with type 2 diabetes mellitus, and this group was divided into two subgroups: 14 patients with diabetic retinopathy (DR group) and 16 patients without DR (NDR group). The control group consisted of 35 non-diabetic cataract subjects.Results: Patients in the DR group had significantly higher aqueous humor concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-10, monocyte chemotactic protein (MCP-1) and VEGF. Likewise, serum concentrations of IL-1β, IL-6, IL-8, IL-12, TNF-α and IFN-γ were significantly higher in the DR group as compared to the controls. Aqueous humor concentrations of IL-1β, IL-8, MCP-1 and VEGF were significantly higher in the DR group as compared with the NDR group.Conclusion: Our findings support the hypothesis that chronic inflammation and a disturbance of the immune system play important roles in the pathogenesis of diabetic cataract and DR.

中文翻译：

---

糖尿病患者水液幽默和血清中某些细胞因子和血管内皮生长因子的浓度。

目的：探讨糖尿病患者选择的细胞因子和血管内皮生长因子（VEGF）的房水和血清水平，提示其在糖尿病眼并发症的发病机制中的作用。材料与方法：共65例（男27例，女38例） ）接受白内障手术的患者被纳入研究。研究组由30例2型糖尿病白内障患者组成，该组分为两个亚组：14例糖尿病性视网膜病变患者（DR组）和16例无DR疾病患者（NDR组）。对照组由35名非糖尿病性白内障患者组成。结果：DR组患者的房水浓度明显高于白细胞介素（IL）-1β，IL-6，IL-8，IL-10，单核细胞趋化蛋白（MCP） -1）和VEGF。同样，IL-1β的血清浓度 与对照组相比，DR组的IL-6，IL-8，IL-12，TNF-α和IFN-γ明显更高。DR组与NDR组相比，IL-1β，IL-8，MCP-1和VEGF的房水浓度明显升高。结论：我们的发现支持以下假设：慢性炎症和免疫系统紊乱起着重要的作用。在糖尿病性白内障和DR的发病中的作用。