The intestinal ecosystem is involved in the pathogenesis of mood disorders such as depression. Intestinal microbes can affect the central nervous system through the gut-brain axis, which raises the possibility of using probiotics for preventing depression. In this study, we examined the effect of heat-inactivated Lactobacillus gasseri CP2305 (CP2305) in a subchronic and mild social defeat stress (sCSDS) mouse model. sCSDS suppressed food intake. However, dietary CP2305 intake rescued it, suggesting that CP2305 improved the decreased appetite in sCSDS mice. sCSDS did not alter the gene expression of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 in the hippocampus. However, dietary CP2305 provided following sCSDS increased the gene expression of these neurotrophins in the hippocampus. These findings suggest that CP2305 supplementation would aid in preventing psychosocial stress-induced disorders.

中文翻译：

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饮食摄入热灭活的加氏乳杆菌CP2305对在亚慢性和轻度社会挫败应激小鼠模型中应激诱导的行为和分子变化的影响。

肠道生态系统参与抑郁症等情绪障碍的发病机制。肠道微生物可通过肠脑轴影响中枢神经系统，这增加了使用益生菌预防抑郁的可能性。在这项研究中，我们研究了热失活的加氏乳杆菌CP2305（CP2305）在亚慢性和轻度社交衰竭应激（sCSDS）小鼠模型中的作用。sCSDS抑制了食物摄入。然而，饮食中的CP2305摄入量可以挽救它，这表明CP2305可以改善sCSDS小鼠食欲下降。sCSDS不会改变海马中脑源性神经营养因子，神经生长因子和Neurotrophin-3的基因表达。但是，在sCSDS之后提供的饮食CP2305增加了海马中这些神经营养蛋白的基因表达。