The development of a standardized HLA nomenclature has been critical in our understanding of the HLA system and in facilitating the clinical applications of HLA. The Nomenclature Committee for Factors of the HLA System, established in 1968, has overseen the development and usage of nomenclature based on serologic specificities, cellular responses, and DNA sequences. Their decisions have been guided by community consensus reached through 17 international workshops beginning in 1964 and continuing today. Two websites provide a curated database of the sequences of over 26,000 HLA alleles and a reference site for the current nomenclature. This review covers the major steps in the development of the HLA nomenclature as well as the efforts of other groups to extend its usefulness for research and clinical applications.

标准化 HLA 命名法的发展对于我们理解 HLA 系统和促进 HLA 的临床应用至关重要。HLA 系统因素命名委员会成立于 1968 年，负责监督基于血清学特异性、细胞反应和 DNA 序列的命名法的开发和使用。他们的决定是根据从 1964 年开始并持续至今的 17 次国际研讨会达成的社区共识指导的。两个网站提供了超过 26,000 个 HLA 等位基因序列的精选数据库和当前命名法的参考位点。本综述涵盖了 HLA 命名法发展的主要步骤，以及其他团体为扩展其在研究和临床应用中的实用性所做的努力。