Several models of environmental enrichment and physical exercise have been used to explore the experience effects on brain functions and plasticity, mainly in adult animals. In order to examine the early influence of these stimuli on developing brain, the present study used calcium-binding protein parvalbumin as neuroplastic marker in the hippocampal formation of male Wistar rats subjected to environmental enrichment or physical exercise from postnatal days 21 to 60 (P21-P60). In our study, no significant difference in hippocampal expression and distribution of parvalbumin was found between enriched and control rats. However, a significant increase in parvalbumin protein expression as well as in the number of neurons stained with parvalbumin was observed in the hippocampal formation of rats submitted to daily treadmill exercise when compared to the control rats. The hippocampal region with the highest number of parvalbumin neurons in exercised rats was Cornus of Amon 2 e 3 (CA2/CA3). These findings indicate that developing brain may be differentially sensitive to environmental stimulation models. Specifically, our results show that hippocampal expression and distribution of parvalbumin in developing rats may be more influenced by exercise than by enriched environment. The mechanisms are not yet known.

中文翻译：

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丰富的环境和运动对发育中大鼠海马形成中小清蛋白表达和分布的影响。

几种环境丰富和体育锻炼的模型已被用于探索体验对大脑功能和可塑性的影响，主要是在成年动物中。为了检查这些刺激对发育中大脑的早期影响，本研究使用钙结合蛋白小清蛋白作为在出生后第 21 天至第 60 天（P21- P60）。在我们的研究中，在富集大鼠和对照大鼠之间没有发现海马表达和小清蛋白分布的显着差异。然而，与对照大鼠相比，在每天进行跑步机运动的大鼠的海马结构中，观察到小清蛋白表达以及被小清蛋白染色的神经元数量显着增加。运动大鼠中小清蛋白神经元数量最多的海马区是阿蒙角 2 e 3 (CA2/CA3)。这些发现表明发育中的大脑可能对环境刺激模型具有不同的敏感性。具体而言，我们的结果表明，发育中大鼠海马区小清蛋白的表达和分布可能更受运动而非丰富环境的影响。其机制尚不清楚。这些发现表明发育中的大脑可能对环境刺激模型具有不同的敏感性。具体而言，我们的结果表明，发育中大鼠海马区小清蛋白的表达和分布可能更受运动而非丰富环境的影响。其机制尚不清楚。这些发现表明发育中的大脑可能对环境刺激模型具有不同的敏感性。具体而言，我们的结果表明，发育中大鼠海马区小清蛋白的表达和分布可能更受运动而非丰富环境的影响。其机制尚不清楚。