Staphylococci are common commensals on human epithelial surfaces. Some species, most notably Staphylococcus aureus, have considerable pathogenic potential and can cause severe and sometimes fatal infections. Despite the long-known fact that staphylococcal infection arises from colonizing isolates, research on staphylococcal colonization has been limited, in particular regarding interactions with the colonizing microbiota. However, several recent studies are beginning to decipher such interactions, which range from bacteriocin-based or signaling interference-mediated inhibitory interactions to cooperation with host defenses to outcompete co-colonizers. This review will give an outline of recent research on the mechanistic underpinnings of staphylococcal interference with other members of the colonizing microbiota, some of which suggest new avenues for the development of novel anti-infectives or decolonization strategies.

中文翻译：

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人类微生物组中的葡萄球菌：宿主和细菌间相互作用的作用。

葡萄球菌是人类上皮表面的常见标志。一些物种，最引人注目的是金黄色葡萄球菌，具有相当大的致病潜力，并可能导致严重的感染甚至致命的感染。尽管葡萄球菌感染是由定居菌产生的，这是众所周知的事实，但对葡萄球菌定植的研究仍然很有限，特别是在与定植菌群的相互作用方面。但是，最近的一些研究开始破译这种相互作用，范围从基于细菌素的或信号传导的干扰介导的抑制性相互作用，到与宿主防御的协同作用，甚至胜过共殖民者。这项审查将概述葡萄球菌干扰定居微生物群其他成员的机制基础的最新研究，