Introduction: Pseudomonas aeruginosa is a common, ubiquitous bacterium that is found in natural environments but is also a successful opportunistic pathogen of humans and plants. The reasons for this flexibility and evolutionary success can be attributed to its ability to readily acquire new genes to ensure its survival enabling it to survive desiccation, the action of antimicrobial compounds and invade new territories such as modern hospitals with high levels of antibiotic usage.Areas covered: Literature was searched using PubMed and Web of science (05/19 to 05/20). Identified studies paint a picture of a dynamic, highly variable population shaped by frequent intra- and inter-species horizontal gene transfer resulting in a species able to resist the action of antibiotics and deploy multiple virulence strategies controlled by complex quorum-sensing systems. We investigate possible control measures including anti-virulence and environmental control measures.Expert opinion: P. aeruginosa is a resilient, richly diverse species but also a global health threat due to the emergence and global dissemination of successful multiresistant clones that resist all antibiotics. Genomics offers the potential for rapid identification of 'high-risk' clones to guide chemotherapy, but novel control measures are also required to slow the species progression to pan-resistance.

中文翻译：

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进一步了解铜绿假单胞菌水平获得毒力的能力：可能的干预策略。

简介：铜绿假单胞菌是一种常见的普遍存在的细菌，可在自然环境中发现，但也是人类和植物的成功机会致病菌。这种灵活性和进化成功的原因可归因于其能够轻易获得新基因以确保其存活使其能够在干燥中存活的能力，抗微生物化合物的作用并侵入新领域，例如抗生素用量高的现代医院。涵盖：使用PubMed和Web of Science（05/19至05/20）搜索文学。已确定的研究描绘了动态，高度可变的种群由频繁的种内和种间水平基因转移形成，从而使该物种能够抵抗抗生素的作用并部署由复杂群体感应系统控制的多种毒力策略。我们调查了可能的控制措施，包括抗毒力和环境控制措施。专家意见：铜绿假单胞菌是一种有韧性的，种类繁多的物种，但由于能够抵抗所有抗生素的成功的多抗性克隆的出现和全球传播，它也对全球健康构成威胁。基因组学为快速鉴定“高危”克隆提供指导化学疗法的潜力，但还需要采取新颖的控制措施来减缓物种向泛抗性的发展。我们调查了可能的控制措施，包括抗毒力和环境控制措施。专家意见：铜绿假单胞菌是一种有韧性的，种类繁多的物种，但由于能够抵抗所有抗生素的成功的多抗性克隆的出现和全球传播，它也对全球健康构成威胁。基因组学提供了快速鉴定“高风险”克隆以指导化学疗法的潜力，但还需要采取新颖的控制措施来减缓物种向泛抗性的进程。我们调查了可能的控制措施，包括抗毒力和环境控制措施。专家意见：铜绿假单胞菌是一种有韧性的，种类繁多的物种，但由于能够抵抗所有抗生素的成功的多抗性克隆的出现和全球传播，它也对全球健康构成威胁。基因组学提供了快速鉴定“高风险”克隆以指导化学疗法的潜力，但是还需要采取新颖的控制措施来减缓物种向泛抗性的发展。