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Ammonium Salts Increase Physical Performance and Reduce Blood Lactate Level in Rats in a Model of Forced Swimming
Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2020-03-01 , DOI: 10.1007/s10517-020-04762-4
E A Korf 1 , I V Mindukshev 1 , A V Novozhilov 1 , A I Krivchenko 1 , N V Goncharov 1
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We compared the effects of two doses of ammonium chloride and ammonium carbonate (10 and 20 mg/kg) on the duration of swimming and blood lactate level. Ammonium chloride in a dose of 20 mg/kg was more efficient than in a dose of 10 mg/kg. The efficiency of ammonium carbonate in a dose of 10 mg/kg was similar to that of ammonium chloride in a dose of 20 mg/kg. Increasing the dose of ammonium carbonate to 20 mg/kg led to a decrease in the duration of swimming. On the last day of the experiment, lactate level in 5 min after exhausting load was maximum in control rats, while in rats treated with 10 mg/kg ammonium carbonate and 20 mg/kg ammonium chloride it was lower by 27 and 33%, respectively. In the control group, the amplitude of the decrease in lactate concentration in 1 h after load was 2-fold greater than in the group receiving ammonium chloride in a dose of 20 mg/kg and 1.6-fold greater that in groups treated with ammonium carbonate in a dose of 10 mg/kg and ammonium chloride in a dose of 20 mg/kg.

中文翻译:

在强迫游泳模型中,铵盐可提高大鼠的体能表现并降低其血乳酸水平

我们比较了两种剂量的氯化铵和碳酸铵(10 和 20 毫克/千克)对游泳时间和血乳酸水平的影响。20 mg/kg 剂量的氯化铵比 10 mg/kg 剂量更有效。10mg/kg剂量的碳酸铵的效率与20mg/kg剂量的氯化铵的效率相似。将碳酸铵的剂量增加到 20 mg/kg 导致游泳时间减少。在实验的最后一天,对照组大鼠在力竭负荷后 5 分钟内的乳酸水平最高,而用 10 mg/kg 碳酸铵和 20 mg/kg 氯化铵处理的大鼠分别降低了 27% 和 33% . 在对照组中,
更新日期:2020-03-01
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