We studied the correlations of the expression of Ki-67 proliferation marker and localization of heat shock protein Hsp70 in tumor cells of papillary thyroid cancer with some clinical and morphological parameters and a 10-year survival prognosis. High variability of the proliferative activity (by Ki-67 index) of tumor cells was revealed. It was found that Hsp70 protein has different localization in tumor cells: cytoplasmic, nuclear, nucleolar, and mixed. Nuclear translocation of the Hsp70 protein correlated with the stage of the process and the prognosis of the disease, but did not correlate with sex, tumor size, capsule invasion, and lymph node metastasis. Ki-67 index of tumor cells correlated with sex, stage of the process, size of tumor formation and prognosis, but did not correlated with age, invasion into the capsule and metastasis to the lymph nodes. Depending on the variants of Hsp70 and Ki-67 co-expression, three molecular types of papillary thyroid cancer can be distinguished: favorable, intermediate, and poor prognosis.

中文翻译：

---

Ki-67、Hsp70免疫表达与甲状腺乳头状癌临床形态学参数及预后的关系

我们研究了甲状腺乳头状癌肿瘤细胞中 Ki-67 增殖标志物的表达和热休克蛋白 Hsp70 的定位与一些临床和形态学参数以及 10 年生存预后的相关性。揭示了肿瘤细胞增殖活性（通过 Ki-67 指数）的高度可变性。发现Hsp70蛋白在肿瘤细胞中具有不同的定位：细胞质、核、核仁和混合。Hsp70 蛋白的核转位与该过程的阶段和疾病的预后相关，但与性别、肿瘤大小、包膜浸润和淋巴结转移无关。肿瘤细胞的 Ki-67 指数与性别、过程阶段、肿瘤形成大小和预后相关，但与年龄无关，侵入包膜并转移至淋巴结。根据 Hsp70 和 Ki-67 共表达的变异，可以区分三种分子类型的甲状腺乳头状癌：预后良好、中等和预后不良。