We analyzed the content of β-catenin fractions and activity and content of proteasomes in the tissues of patients with non-small cells lung cancer. The content of β-catenin fractions was elevated and proteasome-dependent proteolysis in the tumor tissue was enhanced in comparison with the corresponding unchanged lung tissue. A negative regression relationship of caspase-like activity of proteasomes and a positive correlation between the content of proteasomes and both fractions of β-catenin were found. We hypothesize that proteasomes are involved in the degradation of β-catenin due to caspase-like activity.

中文翻译：

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非小细胞肺癌中的β-连环蛋白及其与蛋白酶体的关联

我们分析了非小细胞肺癌患者组织中β-连环蛋白组分的含量和蛋白酶体的活性和含量。与相应的未改变肺组织相比，β-连环蛋白组分的含量升高，肿瘤组织中蛋白酶体依赖性蛋白水解作用增强。发现蛋白酶体的半胱天冬酶样活性呈负回归关系，蛋白酶体含量与 β-连环蛋白的两个部分之间呈正相关。我们假设蛋白酶体由于类半胱天冬酶的活性参与了 β-连环蛋白的降解。