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Peptide KE in Human Proteome
Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2020-03-01 , DOI: 10.1007/s10517-020-04767-z
A Yu Terekhov 1 , D Yu Kormilets 2 , N S Linkova 2, 3 , B I Kuznik 4 , A T Mar'yanovich 1 , V Kh Khavinson 2, 5
Affiliation  

Peptide KE exhibits immunoprotective, geroprotective, and oncostatic activities and stimulates functional activity of fibroblasts. The KE motif is present in amino acid sequences of some cytokines and peptide hormones functionally similar to KE peptide. However, the relationship between the presence of KE motif and protein functions on the scale of known human proteome has not yet received sufficient attention. The incidence of bioregulatory peptide KE in proteins of various functional groups constituting human proteome is studied. The study is carried out with the use of the available data on the human proteome (UniProt portal) comprising 20,417 proteins. The levels of KE motifs were maximum in cytoplasmic and nuclear proteins, while the presence of KE in the membrane and all other proteins was the minimum. KE peptide molecules released from nuclear proteins during limited proteolysis can bind to DNA and regulate gene expression.

中文翻译:

人类蛋白质组中的肽 KE

肽 KE 具有免疫保护、老年保护和肿瘤抑制活性,并刺激成纤维细胞的功能活性。KE 基序存在于一些细胞因子和肽激素的氨基酸序列中,其功能与 KE 肽相似。然而,在已知人类蛋白质组的规模上,KE 基序的存在与蛋白质功能之间的关系尚未得到足够的关注。研究了构成人类蛋白质组的各种功能组的蛋白质中生物调节肽 KE 的发生率。该研究是利用包含 20,417 种蛋白质的人类蛋白质组(UniProt 门户)的可用数据进行的。KE 基序的水平在细胞质和核蛋白中最高,而 KE 在膜和所有其他蛋白质中的存在最低。
更新日期:2020-03-01
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