Staphylococcus aureus is an opportunistic pathogen that normally colonizes the human anterior nares. At the same time, this pathogen is one of the leading causes of life-threatening bloodstream infections, such as sepsis and endocarditis. In this review we will present the current understanding of the pathogenesis of these invasive infections, focusing on the mechanisms of S. aureus clearance from the bloodstream by the immune system, and how this pathogen hijacks the host defense and coagulation systems and further interacts with the blood vessel endothelium. Additionally, we will delve into the regulatory mechanisms S. aureus employs during an invasive infection. These new insights into host-pathogen interactions show promising avenues for the development of novel therapies for treating bloodstream infections.

中文翻译：

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金黄色葡萄球菌血流感染：发病机理和调节机制。

金黄色葡萄球菌是一种机会性病原体，通常定植在人类前鼻孔中。同时，这种病原体是威胁生命的血液感染的主要原因之一，例如败血症和心内膜炎。在这篇综述中，我们将介绍当前对这些侵袭性感染的发病机理的理解，重点是免疫系统从血液中清除金黄色葡萄球菌的机制，以及该病原体如何劫持宿主防御系统和凝血系统，并进一步与细菌相互作用。血管内皮。此外，我们将深入研究金黄色葡萄球菌在侵入性感染过程中采用的调控机制。这些对宿主-病原体相互作用的新见解显示了开发用于治疗血流感染的新疗法的有希望的途径。