Hepatoprotective homoisoflavonoids from the fruits of Cucumis bisexualis.,Journal of Food Biochemistry

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Hepatoprotective homoisoflavonoids from the fruits of Cucumis bisexualis.
Journal of Food Biochemistry ( IF 4 ) Pub Date : 2020-05-04 , DOI: 10.1111/jfbc.13264
Qinge Ma ₁ , Rongrui Wei ₁ , Zhipei Sang ₂

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Cucumis bisexualis has been widely served as a beneficial wild fruit in China. Four new homoisoflavonoids (1–4), together with eight known homoisoflavonoid derivatives (5–12) were isolated from the 90% EtOH extract of C. bisexualis, using repeated open column chromatography and preparative thin‐layer chromatography. They were elucidated based on the analysis of spectral data and references from the fruits of C. bisexualis for the first time. These compounds (1–12) were evaluated for their in vitro inhibitory effects against the increase of aspartate aminotransferase and alanine aminotransferase levels in H₂O₂‐induced HepG2 cells in the range of their maximum nontoxic concentration. Among them, compounds 3, 4, 8, and 9 exhibited certain hepatoprotective activities.

更新日期：2020-05-04

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