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Mechanism of tumor cells escaping from immune surveillance of NK cells.
Immunopharmacology and Immunotoxicology ( IF 3.3 ) Pub Date : 2020-03-29 , DOI: 10.1080/08923973.2020.1742733
Zhe Ge 1, 2 , Shan Wu 1, 2 , Zhe Zhang 1, 2 , Shuzhe Ding 1, 2
Affiliation  

Natural killer (NK) cells play an important role in anti-tumor and anti-infection, and perform their immune surveillance function in various ways. However, no matter what kind of cancer, the functional activity of NK cells in the tumor microenvironment (TME) is suppressed. Understanding the relationship between tumor cells and NK cells is very critical for tumor immunotherapy. This review discusses the mechanism of tumor cells escaping the immune surveillance of NK cells. These include a variety of factors that inhibit the activity of NK cells, an imbalance of activating receptors and inhibiting receptors on NK cells, abnormal binding of receptors and ligands, cross-talk of surrounding cell groups and NK cells in the TME, and other factors that affect NK cell activity. An understanding of these factors is necessary to provide new treatment strategies for tumor immunotherapy.

中文翻译:

肿瘤细胞逃避NK细胞免疫监视的机制。

天然杀伤(NK)细胞在抗肿瘤和抗感染方面起着重要作用,并以各种方式执行其免疫监视功能。但是,无论哪种癌症,肿瘤微环境(TME)中NK细胞的功能活性均受到抑制。了解肿瘤细胞和NK细胞之间的关系对于肿瘤免疫疗法非常重要。这篇综述讨论了肿瘤细胞逃避NK细胞免疫监视的机制。这些因素包括多种抑制NK细胞活性的因子,NK细胞上激活受体和抑制受体的失衡,受体和配体的异常结合,TME中周围细胞群与NK细胞的串扰以及其他因素影响NK细胞的活性。
更新日期:2020-03-29
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