Nitrous oxide is a common gas used as an anesthetic agent and analgesic medication in operating rooms. The gas inhibits vitamin B12 dependent-methionine synthase, which converts L-homocysteine and 5-methyltetrahydrofolate to L-methionine and tetrahydrofolate, respectively, via a methylation process. The immune system has been frequently reported to be suppressed in anesthetized subjects during the postoperative period. Although previous reviews have focused on the pathophysiologic role of nitrous oxide, none of them has considered the harmful effects of nitrous oxide on the Defense system of the host. In this article, the authors review current studies on the effects of nitrous oxide on the immune system of both patients undergoing surgery and occupational exposure, as well as preclinical studies. Moreover, this paper opens a new horizon for future studies in the context of underlying mechanisms of nitrous oxide actions on the immune system.

中文翻译：

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麻醉气体一氧化二氮对免疫系统影响的综述；未来体验的起点。

一氧化二氮是在手术室中用作麻醉剂和止痛药的常见气体。该气体抑制维生素B12依赖性蛋氨酸合成酶，后者通过甲基化过程将L-高半胱氨酸和5-甲基四氢叶酸分别转化为L-蛋氨酸和四氢叶酸。据报道，在术后期间，麻醉对象的免疫系统受到抑制。尽管以前的评论集中在一氧化二氮的病理生理作用上，但没有人考虑过一氧化二氮对宿主防御系统的有害作用。在本文中，作者回顾了当前关于一氧化二氮对接受手术和职业暴露的患者的免疫系统影响的研究以及临床前研究。此外，