当前位置: X-MOL 学术J. Inorg. Biochem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Solvent induced supramolecular polymorphism in Cu(II) coordination complex built from 1,2,4-triazolo[1,5-a]pyrimidine: Crystal structures and anti-oxidant activity.
Journal of Inorganic Biochemistry ( IF 3.9 ) Pub Date : 2020-05-05 , DOI: 10.1016/j.jinorgbio.2020.111092
Karim Chkirate 1 , Saad Fettach 2 , Mohamed El Hafi 1 , Khalid Karrouchi 3 , Bouchaib Elotmani 1 , Joel T Mague 4 , Smaail Radi 5 , My El Abbes Faouzi 2 , N N Adarsh 6 , El Mokhtar Essassi 1 , Yann Garcia 6
Affiliation  

Two Cu(II) coordination complexes, C1 and C2 of the formula [Cu(4)2(H2O)2], have been prepared by reaction between CuCl2·2H2O and 7-ethoxycarbonylmethyl-5-methyl-1,2,4[1,5-a]pyrimidine (L) in a 1:2 M:L molar ratio. The L molecule decomposes during the reaction process into 7-carboxy-5-methyl-[1,2,4]-triazolo[1,5-a]pyrimidine (4) through an intermediate, ethyl 2,2-dihydroxy-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)acetate (5), which has been isolated and its crystal structure determined by X-ray diffraction. The X-ray analysis of the single crystals of [Cu(4)2(H2O)2] obtained from the slow evaporation of EtOH and MeOH, separately, revealed the formation of “solvent induced” polymorphs C1 and C2, respectively. The primary supramolecular synthon for C1 and C2 are six membered ring, and square shaped hydrogen bonded architecture, respectively. The self-assembly of such synthons resulted in a two dimensional hydrogen bonded sheet supported by OH⋯O interactions. In addition, the antioxidant properties of the ligands and its complexes were evaluated in vitro using 1,1-diphenyl-2-picrylhydrazyl acid, 2,2′-azino-bis (3-ethylbenzothiazoline-6 sulfonic acid radical scavenging methods and ferric reducing antioxidant power.



中文翻译:

溶剂诱导的由1,2,4-三唑并[1,5-a]嘧啶构建的Cu(II)配合物的超分子多态性:晶体结构和抗氧化活性。

通过CuCl 2 ·2H 2 O与7-乙氧基羰基甲基-5-甲基-1之间的反应,制备了两种Cu(II)配位化合物C1C2,式[Cu(42(H 2 O)2 ]摩尔比为1:2 M:L的2,4 [1,5-a]嘧啶(L)。在大号在反应过程中分子分解成7-羧基-5-甲基- [1,2,4] -三唑并[1,5-一个]嘧啶(4)通过中间,乙基2,2-二羟基-2- (5-甲基-[1,2,4]三唑并[1,5 - a ]嘧啶-7-基)乙酸酯(5),通过X射线衍射确定其晶体结构。分别通过缓慢蒸发EtOH和MeOH获得的[Cu(42(H 2 O)2 ]单晶的X射线分析表明,分别形成了“溶剂诱导”多晶型物C1C2C1C2的主要超分子合成子分别是六元环和方形氢键结构。这种合成子的自组装产生了由O支撑的二维氢键片H⋯O相互作用。此外,配体及其配合物的抗氧化性能在体外使用1,1-二苯基-2-吡啶并肼基酸,2,2'-叠氮基双(3-乙基苯并噻唑啉-6)磺酸自由基清除方法和三价铁还原反应进行了评估。抗氧化能力。

更新日期:2020-05-05
down
wechat
bug