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A feasibility study for somatomotor cortical mapping in Tourette syndrome using neuronavigated transcranial magnetic stimulation.
Cortex ( IF 3.6 ) Pub Date : 2020-05-04 , DOI: 10.1016/j.cortex.2020.04.014
Hilmar P Sigurdsson 1 , Stephen R Jackson 2 , Soyoung Kim 3 , Katherine Dyke 1 , Georgina M Jackson 3
Affiliation  

Tourette syndrome (TS) is a hyperkinetic movement disorder characterised by the occurrence of chronic motor and vocal tics, and is associated with alterations in the balance of excitatory and inhibitory signalling within key brain networks; in particular the cortical-striatal-thalamic-cortical (CSTC) brain circuits that are implicated in movement selection and habit learning. Converging evidence indicates abnormal brain network function in TS may be largely due to the impaired operation of GABA signalling within the striatum and within cortical motor areas, leading to the occurrence of tics. TS has been linked to a heightened sensitivity to somatic stimulation and altered processing of somatosensory information, and there is evidence to indicate that alterations in GABAergic function is likely to contribute to altered somatomotor function. Based upon this evidence, we hypothesised that the specificity of somatomotor representations in primary motor cortex would likely be reduced in individuals with TS. To test this, we used a rapid acquisition method together with neuronavigated transcranial magnetic stimulation (nTMS) to measure the cortical representation of a several different muscles in a group of young adults with TS and a matched group of typically developing individuals.



中文翻译:

应用神经导航经颅磁刺激在抽动秽语综合征中进行体动皮层定位的可行性研究。

Tourette综合征(TS)是一种运动亢进性疾病,其特征是发生慢性运动和发声抽动,并与关键脑网络内兴奋性和抑制性信号平衡的改变有关;特别是涉及运动选择和习惯学习的皮质-纹状体-丘脑-皮质(CSTC)脑回路。越来越多的证据表明,TS中的大脑网络功能异常可能主要是由于纹状体内和皮质运动区域内GABA信号传导的受损,导致抽动症的发生。TS与提高对体细胞刺激的敏感性和改变体感信息的处理有关,并且有证据表明,GABA能功能的改变很可能导致体动功能的改变。基于此证据,我们假设在TS个体中原代运动皮层中躯体运动表征的特异性可能会降低。为了测试这一点,我们使用了一种快速采集方法以及神经导航经颅磁刺激(nTMS)来测量一组患有TS的年轻成年人和一组典型的发育中个体的几种不同肌肉的皮层表现。

更新日期:2020-05-04
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