The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 and causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. Therefore, rapid and accurate identification of pathogenic viruses plays a vital role in selecting appropriate treatments, saving people's lives and preventing epidemics. Additionally, general treatments, coronavirus-specific treatments, and antiviral treatments useful in fighting COVID-19 are addressed. This review sets out to shed light on the SARS-CoV-2 and host receptor recognition, a crucial factor for successful virus infection and taking immune-informatics approaches to identify B- and T-cell epitopes for surface glycoprotein of SARS-CoV-2. A variety of improved or new approaches also have been developed. It is anticipated that this will assist researchers and clinicians in developing better techniques for timely and effective detection of coronavirus infection. Moreover, the genomic sequence of the virus responsible for COVID-19, as well as the experimentally determined three-dimensional structure of the Main protease (Mpro) is available. The reported structure of the target Mpro was described in this review to identify potential drugs for COVID-19 using virtual high throughput screening.

中文翻译：

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对Sars-CoV-2（Covid-19）进行虚拟筛选和抗病毒治疗相结合的研究。

最近一种称为SARS-CoV-2的新型人类冠状病毒的流行病爆发并引起呼吸道疾病COVID-19引起了全世界的共鸣，并且正在全球范围内努力表征这种病毒的分子特征和进化起源。因此，快速准确地识别病原病毒在选择适当的治疗方法，挽救生命和预防流行病方面起着至关重要的作用。另外，提出了可用于对抗COVID-19的常规治疗，冠状病毒特异性治疗和抗病毒治疗。这篇综述着手阐明SARS-CoV-2和宿主受体的识别，这是成功感染病毒的关键因素，并采用免疫信息学方法鉴定SARS-CoV-2表面糖蛋白的B细胞和T细胞表位。还已经开发了各种改进的或新的方法。预计这将有助于研究人员和临床医生开发更好的技术，以及时有效地检测冠状病毒感染。此外，还提供了负责COVID-19的病毒的基因组序列以及实验确定的主蛋白酶（Mpro）的三维结构。在这篇综述中描述了目标Mpro的报道结构，以使用虚拟高通量筛选来鉴定COVID-19的潜在药物。以及实验确定的主蛋白酶（Mpro）的三维结构。在这篇综述中描述了目标Mpro的报道结构，以使用虚拟高通量筛选来鉴定COVID-19的潜在药物。以及实验确定的主蛋白酶（Mpro）的三维结构。在这篇综述中描述了目标Mpro的报道结构，以使用虚拟高通量筛选来鉴定COVID-19的潜在药物。