Objective

Accelerated loss of muscle mass is common in patients with chronic kidney disease (CKD). Various factors associated with CKD, such as nutritional deficiencies, metabolic acidosis, and chronic inflammation, contribute to muscle wasting. This study aimed to investigate the relationship between CKD and handgrip strength (HGS) in the Korean population.

Design and Methods

This is a population-based, cross-sectional study of a nationally representative sample of 18,765 patients aged ≥19 years from the Korea National Health and Nutrition Examination Survey in 2014–2017. We measured HGS using a digital hand dynamometer and determined the cutoff for low HGS by deriving -2 standard deviation values of sex-matched healthy young adults (19-39 years old). We defined CKD as eGFR <60 mL/min/1.73 m² or the presence of CKD based on a self-reported questionnaire.

Results

The prevalence of CKD was 4.0% in the total population. The cutoff values for the low HGS were 29.5 kg for men and 16.8 kg for women. The prevalence of low HGS was 6.2% in patients without CKD, and 25.2% in patients with CKD. There was a significant correlation between HGS and eGFR in both men and women. In multivariate logistic regression adjusted by age group, diabetes, hypertension, and obesity, CKD showed an independent relationship with low HGS in both men (odds ratio [OR] 1.910, 95% confidence interval [CI] 1.468-2.485) and women (OR 1.570, 95% CI 1.202-2.052).

Conclusions

The prevalence of low HGS was higher in patients with CKD. We suggest that the sarcopenia should be evaluated in patients with CKD.

中文翻译：

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低握力与慢性肾病的关系：KNHANES 2014-2017。

客观的

慢性肾病 (CKD) 患者的肌肉质量加速减少很常见。与 CKD 相关的各种因素，如营养缺乏、代谢性酸中毒和慢性炎症，都会导致肌肉萎缩。本研究旨在调查韩国人群中 CKD 与握力 (HGS) 之间的关系。

设计和方法

这是一项基于人群的横断面研究，对 2014-2017 年韩国国家健康和营养检查调查中 18,765 名 19 岁以上患者的全国代表性样本进行了研究。我们使用数字手测力计测量了 HGS，并通过推导出性别匹配的健康年轻人（19-39 岁）的 -2 标准偏差值来确定低 HGS 的临界值。我们根据自我报告的问卷将 CKD 定义为 eGFR <60 mL/min/1.73 m ²或存在 CKD。

结果

CKD 在总人口中的患病率为 4.0%。男性低 HGS 的临界值为 29.5 公斤，女性为 16.8 公斤。非 CKD 患者的低 HGS 患病率为 6.2%，CKD 患者为 25.2%。男性和女性的 HGS 和 eGFR 之间存在显着相关性。在按年龄组、糖尿病、高血压和肥胖调整的多变量逻辑回归中，CKD 在男性（优势比 [OR] 1.910，95% 置信区间 [CI] 1.468-2.485）和女性（OR 1.570, 95% CI 1.202-2.052)。

结论

CKD 患者低 HGS 的患病率较高。我们建议应评估 CKD 患者的肌肉减少症。