Aging is a global burden, and the increase in life span does not increase in parallel with health span. Therefore, older adults are currently living longer with chronic diseases, increased infections, and cancer. A characteristic of aging is the presence of chronic low-grade inflammation that is characterized by elevated concentrations of IL-6, TNF-α, and C-reactive protein, which has been termed inflammaging. Previous studies have demonstrated that chronic inflammation interferes with T-cell response and macrophage function and is also detrimental for vaccine responses. This raises the question of whether therapeutic strategies that reduce inflammation may be useful for improving immunity in older adults. In this review we discuss the potential causes of inflammaging, the cellular source of the inflammatory mediators, and the mechanisms by which inflammation may inhibit immunity. Finally, we describe existing interventions that target inflammation that have been used to enhance immunity during aging.

中文翻译：

---

阻止炎症可以增强衰老过程中的免疫力吗？

衰老是全球性的负担，寿命的增加不会与健康的寿命同时增加。因此，老年人目前患有慢性疾病，感染增加和癌症的寿命更长。衰老的特征是存在慢性低度炎症，其特征在于升高的IL-6，TNF-α和C反应蛋白的浓度，这被称为发炎。先前的研究表明，慢性炎症会干扰T细胞反应和巨噬细胞功能，并且也不利于疫苗反应。这就提出了一个问题，即减少炎症的治疗策略是否可用于提高老年人的免疫力。在这篇综述中，我们讨论了炎症的潜在原因，炎症介质的细胞来源，以及炎症可能抑制免疫力的机制。最后，我们描述了针对炎症的现有干预措施，这些干预措施已用于在衰老过程中增强免疫力。