Oxyntomodulin (OXM) is a proglucagon-derived peptide that suppresses hunger in humans. There are some differences in its food intake-inhibitory effects among species. The central mechanisms are unclear and it is unknown if OXM is more efficacious in a gallinaceous species that has not undergone as much selection for growth as the chicken. The objective was thus to determine the effects of OXM on food and water intake and hypothalamic physiology in Japanese quail. At 7 days post-hatch, 6-h-fasted quail were injected intracerebroventricularly (ICV) or intraperitoneally (IP) with 0.32, 0.65, or 1.3 nmol of OXM. All doses decreased food intake for 180 min post-ICV injection. On a cumulative basis, water intake was not affected until 120 min, with the lowest and highest doses decreasing water intake after ICV injection. The two highest doses were anorexigenic when administered via the IP route, whereas all doses were anti-dipsogenic starting at 30 min post-injection. In hypothalamic samples collected at 1-h post-ICV injection, there was an increase in c-Fos immunoreactivity, an indicator of recent neuronal activation, in the arcuate nucleus (ARC) and dorsomedial nucleus (DMN) of the hypothalamus in OXM-injected individuals. Results suggest that quail are more sensitive than chickens to the satiety-inducing effects of OXM. The central mechanism is likely mediated through a pathway in the ARC that is conserved among species, and through activation of the DMN, an effect that is unique to quail. Such knowledge is critical for facilitating the development of novel, side effect-free anti-eating strategies to promote weight-loss in obesity.

中文翻译：

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泌酸调节蛋白诱导饱腹感并激活日本鹌鹑下丘脑的弓形核。

泌酸调节蛋白（OXM）是胰高血糖素衍生的肽，可抑制人类的饥饿感。不同物种对食物摄入的抑制作用存在一些差异。中心机制尚不清楚，还不清楚OXM是否在没有经过像鸡这样多的生长选择的鸡毒种中更有效。因此，目的是确定OXM对日本鹌鹑的食物和水摄入以及下丘脑生理的影响。孵化后第7天，对禁食6小时的鹌鹑进行脑室内（ICV）或腹膜内（IP）注射0.32、0.65或1.3 nmol的OXM。在ICV注射后180分钟，所有剂量均减少食物摄入。从累积的角度来看，进水直到120分钟才受影响，最低和最高剂量会降低ICV注射后的进水量。当通过IP途径给药时，两种最高剂量均具有抗厌食作用，而所有剂量均在注射后30分钟开始具有抗Disogenic作用。在ICV注射后1小时收集的下丘脑样本中，注射OXM的下丘脑的弓形核（ARC）和背体核（DMN）中的c-Fos免疫反应性增加，这是最近神经元激活的指示个人。结果表明，鹌鹑比OXM对鸡的饱腹感更敏感。中心机制可能是通过物种间保守的ARC途径和DMN的激活介导的，而DMN的激活是鹌鹑特有的。这些知识对于促进新型，无副作用的抗饮食策略的发展至关重要，以促进肥胖症的减肥。