This work presents a guideline for managing process safety under continuous flow conditions. In our previous work, we developed a Grignard reaction for use under such conditions. This reaction was completed in seconds and entailed a large amount of heat generation. To manage the heat of reaction, we quantitatively analyzed the reaction rate using ReactIR with a flow cell. The difference between quantitative values from HPLC and ReactIR was less than 1%, and the reaction rate was 94% in 0.4 s. Based on the reaction rate and the heat of reaction, we simulated the distribution of the internal temperature along the tube length and found the maximum difference from the measured internal temperatures to be 5 °C. This accuracy was suitable for evaluating and managing the heat of reaction. Our methodology can facilitate the discussion of process safety under continuous flow conditions.

中文翻译：

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使用在线监测技术管理连续流动条件下的反应热

这项工作提出了在连续流动条件下管理过程安全性的指南。在我们以前的工作中，我们开发了在这种条件下使用的格氏反应。该反应在几秒钟内完成，并产生大量的热量。为了管理反应热，我们使用带有流动池的ReactIR定量分析了反应速率。HPLC和ReactIR的定量值之差小于1％，反应速率在0.4 s内为94％。根据反应速率和反应热，我们模拟了内部温度沿管长的分布，发现与测得的内部温度的最大差值为5°C。该精度适合于评估和管理反应热。