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Are Anaphase Events Really Irreversible? The Endmost Stages of Cell Division and the Paradox of the DNA Double-Strand Break Repair.
BioEssays ( IF 4 ) Pub Date : 2020-05-04 , DOI: 10.1002/bies.202000021
Félix Machín 1, 2, 3 , Jessel Ayra-Plasencia 1, 2
Affiliation  

It has been recently demonstrated that yeast cells are able to partially regress chromosome segregation in telophase as a response to DNA double‐strand breaks (DSBs), likely to find a donor sequence for homology‐directed repair (HDR). This regression challenges the traditional concept that establishes anaphase events as irreversible, hence opening a new field of research in cell biology. Here, the nature of this new behavior in yeast is summarized and the underlying mechanisms are speculated about. It is also discussed whether it can be reproduced in other eukaryotes. Overall, this work brings forwards the need of understanding how cells attempt to repair DSBs when transiting the latest stages of mitosis, i.e., anaphase and telophase.

中文翻译:

后期事件真的不可逆吗?细胞分裂的最后阶段和 DNA 双链断裂修复的悖论。

最近已经证明,作为对 DNA 双链断裂 (DSB) 的反应,酵母细胞能够在末期部分恢复染色体分离,很可能找到用于同源定向修复 (HDR) 的供体序列。这种回归挑战了将后期事件确定为不可逆的传统概念,从而开辟了细胞生物学研究的新领域。在这里,总结了酵母中这种新行为的性质,并推测了潜在的机制。还讨论了它是否可以在其他真核生物中复制。总的来说,这项工作提出了了解细胞在经过有丝分裂的最新阶段(即后期和末期)时如何尝试修复 DSB 的需要。
更新日期:2020-06-29
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